OP Labs 5-Amino-1MQ 10mg

5-Amino-1MQ is a synthetic methylquinolinium derivative designed as a potent inhibitor of nicotinamide N-methyltransferase (NNMT). In biochemical research systems, it modulates metabolic signaling by interfering with NNMT catalytic activity, thereby influencing levels of methylated nicotinamide derivatives and related metabolites. Peptide Sciences+1

NNMT is a cytosolic enzyme that catalyzes methyl transfer from S-adenosyl methionine (SAM) to nicotinamide and related substrates. Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues. Peptide Sciences

In preclinical biochemical settings, inhibition of NNMT by compounds like 5-Amino-1MQ leads to alterations in intracellular NAD⁺ salvage pathways, shifts in methyl donor balance, and downstream metabolic signaling changes. Peptide Sciences

Applications in Research

As a molecular probe to study NNMT function, regulation, and downstream metabolic pathways

To investigate metabolic flux, methylation dynamics, NAD⁺ salvage, and related bioenergetic phenomena

In cellular assays, to test effects of NNMT inhibition on gene expression, metabolite profiling, or metabolic phenotypes

In animal / ex vivo experiments for mechanistic elucidation of metabolic regulation (e.g. adipose tissue, liver)

Experimental behaviour of MOTS-c is influenced by metabolic state, cell type, and peptide concentration.

Buffer composition, pH, and ionic strength may affect peptide stability.

Appropriate controls are recommended.

Intended strictly for laboratory research use.